Sterile Box offers safer surgeries

Rice University students and their mentors have created a sterilization station for surgical instruments that can help minimize risk of infections to patients anywhere in the world.

The station built into a standard 20-foot steel shipping container houses all the equipment necessary to prepare surgical instruments for safe reuse, including a water system for decontamination and a solar-powered autoclave for steam sterilization. Autoclaves are standard in modern hospitals but badly needed in low-resource settings.

After months of design and construction, Douglas Schuler, an associate professor of business and public policy in Rice’s Jones Graduate School of Business, and his team published an article in the open-access journal PLoS ONE detailing trials to validate what they call the Sterile Box.

Rice Professor Maria Oden, director of the university’s Oshman Engineering Design Kitchen and a co-author of the article, said rural areas and small cities in developing countries often have medical facilities with improperly maintained or malfunctioning sterilization equipment or no equipment at all. Unreliable power and inadequate quality control over sterilization are also issues, she said.

“Infection control in the surgical suite really is a big challenge in the developing world,” said Oden, who has seen the challenges firsthand while traveling as part of the Rice 360?: Institute for Global Health. “I was shocked to learn how many surgeries end up with patients developing some manner of infection.”

She said the fact that the Sterile Box is a complete drop-in system is significant.

“The box looks at the problem from a complete system level and makes it easy to implement,” she said. “It’s not just a simple device to clean and sterilize the tools, but a way to manage the process.”

“We tried to really think hard about social context,” Schuler said. “We laid out the elements to minimize human error and water and energy requirements to the extent that we can. I really like that about our design.”

The Rice team added solar panels and electrical storage to the container, as well as water distribution from two tanks, one on the ground that has a hand pump to move water to a 50-gallon tank on the roof. The interior has two rooms: a foyer that separates the sterile processing area from outsiders and the elements and a main area with a small window to pass instruments in and out.

Processing is divided into four stations. At the first station technicians decontaminate instruments in a three-basin sink, removing debris and then soaking them in an enzymatic detergent and scrubbing with nylon brushes before a final rinse. At the second station an electric hotplate heats the steam autoclave that sterilizes the instruments. At the third the instruments are dried on wire racks and then moved to the fourth, a storage cabinet where they await the next surgery.

To keep technicians comfortable, the team incorporated radiant barrier insulation and reflective paint outside and maximized air flow inside with mesh screens over the door and windows, floor vents and two wind-powered turbine fans in the ceiling. A battery pack tied to the solar panels powers outlets for fans and cellphone charging.

The next step will be to test the Sterile Box in a clinical setting. Schuler is working with Dr. Sharmila Anandasabapathy, director of Baylor Global Initiatives at Baylor College of Medicine, to incorporate the box into the planned deployment of its Smart Pod, a mobile surgical suite also to be housed in a modified shipping container. Baylor expects to test its unit near the Malawi capital of Lilongwe in 2017.

Schuler said the Sterile Box may be suitable for other medical situations, including maternal and neonatal care, oral health care and postdisaster relief.

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Category: Features, Technology & Devices